Family: John Otis, Jr. / Mary (Margaret) Jacob (F25209)
m. 10 May 1649 | John Otis (1581-1657) 
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 | Margaret Otis (1589-1654) |
| Alicia Otis (1604-1658) |
| Joan Otis (1610-1611) |
| Elizabeth Otis (1614-1615) |
| Margaret Otis (1619-1670)  |
| Joan Otis (1612-1658) |
| Richard Otis ( -1689) |
| Hannah Otis (1616-1646) |
| Nicholas Jacob (1591-1657)
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| Mary Gilman (1599-1681)
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| Captain John Jacob (1629-1693) |
| Elizabeth Jacob (1632-1725) |
| Sarah Jacob (1634-1701) |
| Hannah Jacob ( -1720) |
| Josiah Jacob (1642-1642) |
| Deborah Loring Jacob (1643-1696) |
| Joseph (John) Jacobs (1646-1707) |
| John Otis, Jr. (1620-1684)
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| Mary (Margaret) Jacob (1632-1683)
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| Mary Otis (1653-1654) |
| Mary Mercy Otis (1654-1733) |
| James Otis (1655-1690) |
| Honorable John Otis (1657-1727) |
| Hannah Otis (1659-1676) |
| Captain Stephen Otis (1661-1733) |
| Honorable Joseph Otis (1665-1754) |
| Job Otis (1667-1758) |
| Elizabeth Otis (1669-1748) |